An agonist of human complement fragment C5a enhances vaccine immunity against Coccidioides infection

Highlights ► The EP67 peptide is an agonist of C5a, and enhanced protective immunity of a live, attenuated vaccine. ► Ep67 was successfully conjugated to the surface of the live, attenuated vaccine strain. ► EP67 enhanced the activation of Th1 and Th17 cells. ► EP67 dampened inflammatory pathology a...

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Veröffentlicht in:	Vaccine 2012-06, Vol.30 (31), p.4681-4690
Hauptverfasser:	Hung, Chiung-Yu, Hurtgen, Brady J, Bellecourt, Michael, Sanderson, Sam D, Morgan, Edward L, Cole, Garry T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Antibodies, Fungal - blood Antigen-presenting cells Antigen-Presenting Cells - immunology C5a CD4 antigen Coccidioides Coccidioides - immunology Coccidioidomycosis Coccidioidomycosis - immunology Coccidioidomycosis - prevention & control Combined vaccines Complement C5a - agonists complement component C5a Dendritic cells Differentiation EP67 Female Fungal Vaccines - immunology Helper cells Humans Immunity Immunity, Cellular Immunoglobulin G Infection Inflammation Interferon-gamma - immunology Interleukin-17 - immunology Leukocytes (neutrophilic) Lung Lymphocytes T Macrophages Major histocompatibility complex Mice Mice, Inbred BALB C Pathogens Peptides - administration & dosage Splenocytes Spores Th1 Cells - immunology Th17 Cells - immunology Transcription factors Vaccine Vaccines Vaccines, Attenuated - immunology
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Beschreibung
Zusammenfassung:	Highlights ► The EP67 peptide is an agonist of C5a, and enhanced protective immunity of a live, attenuated vaccine. ► Ep67 was successfully conjugated to the surface of the live, attenuated vaccine strain. ► EP67 enhanced the activation of Th1 and Th17 cells. ► EP67 dampened inflammatory pathology associated with innate immune response to infection. ► EP67 administration increased lung infiltration of IFN-γ and IL-17A producing CD4+ T cells.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.04.084