Molecular mechanism of Aspergillus fumigatus adherence to host constituents

Highlights ► Adherence to host constituents is a key early step in the pathogenesis of invasive aspergillosis. ► Early studies focused on the identification of fungal proteins as adhesins. ► Recently fungal cell wall and secreted glycans have been implicated in adherence. ► Galactosaminogalactan, a...

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Veröffentlicht in:	Current opinion in microbiology 2011-08, Vol.14 (4), p.375-379
1. Verfasser:	Sheppard, Donald C
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Aspergillus fumigatus Aspergillus fumigatus - genetics Aspergillus fumigatus - pathogenicity Biological and medical sciences Cell Adhesion Cell Wall - metabolism cell wall components conidia epithelial cells extracellular matrix Extracellular Matrix Proteins - metabolism Fundamental and applied biological sciences. Psychology fungal proteins Fungal Proteins - genetics Fungal Proteins - metabolism fungi Gene Expression Regulation, Fungal Genes, Fungal Host-Pathogen Interactions Humans Hyphae - growth & development Invasive Pulmonary Aspergillosis - microbiology ligands mannose Microbiology Miscellaneous Mycology Pathology polysaccharides Polysaccharides - genetics Polysaccharides - metabolism receptors sialic acids Spores, Fungal - growth & development Spores, Fungal - pathogenicity virulence
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Beschreibung
Zusammenfassung:	Highlights ► Adherence to host constituents is a key early step in the pathogenesis of invasive aspergillosis. ► Early studies focused on the identification of fungal proteins as adhesins. ► Recently fungal cell wall and secreted glycans have been implicated in adherence. ► Galactosaminogalactan, a component of the extracellular matrix mediates adherence.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2011.07.006