Nitric Oxide Donor Exisulind Is an Effective Inhibitor of Murine Photocarcinogenesis

NO‐releasing nonsteroidal anti‐inflammatory drugs (NO‐NSAIDs) have been shown to have anti‐inflammatory, antiproliferative and apoptosis‐inducing effects in tumor cells. Herein, we have investigated the effects of NO‐exisulind on the growth of UVB‐induced skin tumor development in a murine model. We...

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Veröffentlicht in:	Photochemistry and photobiology 2012-09, Vol.88 (5), p.1141-1148
Hauptverfasser:	Singh, Tripti, Chaudhary, Sandeep C., Kapur, Puneet, Weng, Zhiping, Elmets, Craig A., Kopelovich, Levy, Athar, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism bcl-Associated Death Protein - genetics bcl-Associated Death Protein - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cadherins - genetics Cadherins - metabolism Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - pathology Cells Cyclin D1 - genetics Cyclin D1 - metabolism Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - radiation effects Fibronectins - genetics Fibronectins - metabolism Gene Expression - drug effects Gene Expression - radiation effects Mice Mice, Hairless Nitric oxide Nitric Oxide Donors - pharmacology Nonsteroidal anti-inflammatory drugs Photochemistry Proteins Rodents Signal Transduction - drug effects Signal Transduction - radiation effects Skin - drug effects Skin - pathology Skin - radiation effects Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Snail Family Transcription Factors Snails - genetics Snails - metabolism Sulindac - analogs & derivatives Sulindac - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Ultraviolet Rays - adverse effects
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Zusammenfassung:	NO‐releasing nonsteroidal anti‐inflammatory drugs (NO‐NSAIDs) have been shown to have anti‐inflammatory, antiproliferative and apoptosis‐inducing effects in tumor cells. Herein, we have investigated the effects of NO‐exisulind on the growth of UVB‐induced skin tumor development in a murine model. We found that the topical treatment with NO‐exisulind significantly reduced UVB‐induced tumors in SKH‐1 hairless mice. The tumors/tumor bearing mouse, the number of tumors/mouse and tumor volume/mouse decreased significantly (P
ISSN:	0031-8655 1751-1097 1751-1097
DOI:	10.1111/j.1751-1097.2012.01093.x