The symphony of the ninth: the development and function of Th9 cells

Highlights ► Th9 cells are a T helper cell subset that secretes IL-9 as a signature cytokine. ► Th9 cell development requires transcription factors including PU.1, IRF4 and STAT6. ► Th9 cells promote inflammation in autoimmunity and allergic disease.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in immunology 2012-06, Vol.24 (3), p.303-307
Hauptverfasser:	Jabeen, Rukhsana, Kaplan, Mark H
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals CD4 antigen Cell Differentiation Helper cells Humans Inflammatory diseases Interleukin 9 Interleukin-9 - biosynthesis Interleukin-9 - immunology Interleukin-9 - secretion Lymphocytes T Reviews Signal Transduction T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - secretion Transcription, Genetic
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Beschreibung
Zusammenfassung:	Highlights ► Th9 cells are a T helper cell subset that secretes IL-9 as a signature cytokine. ► Th9 cell development requires transcription factors including PU.1, IRF4 and STAT6. ► Th9 cells promote inflammation in autoimmunity and allergic disease.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.02.001