Genome-wide association study of antibody response to smallpox vaccine

Highlights ► We performed GWAS of antibody levels in a group of 1071 healthy smallpox recipients. ► In African-Americans, we identified eight novel genetic loci at p ≤ 5 × 10−7 . ► Vaccination is the only defense against smallpox. ► Smallpox vaccine has one of the highest complication rates among al...

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Veröffentlicht in:	Vaccine 2012-06, Vol.30 (28), p.4182-4189
Hauptverfasser:	Ovsyannikova, Inna G, Kennedy, Richard B, O’Byrne, Megan, Jacobson, Robert M, Pankratz, V. Shane, Poland, Gregory A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Americans Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Antibody Formation - genetics Antibody response Chromosome 1 chromosome 10 Cohort Studies Ethnic Groups Gene polymorphism Genes Genome-Wide Association Study Genotype GWAS Hispanics Homeobox Humans Humoral immunity Immune response Immunity (humoral) Immunogenetics loci Medical research neutralizing antibodies Polymorphism, Single Nucleotide Promoters Protein kinase C Pseudogenes Replication Runx1 protein Sequence Analysis, DNA Single-nucleotide polymorphism Smallpox Smallpox - prevention & control Smallpox vaccine Smallpox Vaccine - immunology SNPs Statistics Vaccination Vaccines Vaccinia virus Whites Young Adult
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Beschreibung
Zusammenfassung:	Highlights ► We performed GWAS of antibody levels in a group of 1071 healthy smallpox recipients. ► In African-Americans, we identified eight novel genetic loci at p ≤ 5 × 10−7 . ► Vaccination is the only defense against smallpox. ► Smallpox vaccine has one of the highest complication rates among all the vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.04.055