Working memory and the homeostatic control of brain adenosine by adenosine kinase

Highlights ► Global reduction in brain adenosine specifically impairs working memory. ► Elevation of cortical adenosine yielded the same but more severe phenotype. ► Under- and over-activation of A1 and A2A receptors, respectively, appear crucial. ► Normal working memory requires cortical/hippocampa...

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Veröffentlicht in:	Neuroscience 2012-06, Vol.213, p.81-92
Hauptverfasser:	Singer, P, McGarrity, S, Shen, H.-Y, Boison, D, Yee, B.K
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - metabolism Adenosine kinase Adenosine Kinase - metabolism Adenosine receptors Animal models Animals Antagonists Biological and medical sciences Brain Brain - metabolism Caffeine Cognitive ability Cortex Cortex (motor) Enzymes Fundamental and applied biological sciences. Psychology glutamate Glutamic acid receptors Hippocampus Homeostasis Homeostasis - physiology Learning Maze Learning - physiology Medical sciences Memory Memory, Short-Term - physiology Mice Mice, Mutant Strains MK-801 N-Methyl-D-aspartic acid receptors Nervous system Neurology Neuromodulation Neuropharmacology NMDA receptor Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology radial arm maze Receptors, N-Methyl-D-Aspartate - metabolism Short term memory spatial memory Telencephalon Transgenes Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Global reduction in brain adenosine specifically impairs working memory. ► Elevation of cortical adenosine yielded the same but more severe phenotype. ► Under- and over-activation of A1 and A2A receptors, respectively, appear crucial. ► Normal working memory requires cortical/hippocampal adenosine homeostasis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.051