Synthesis of cyclic oligonucleotides by a modified phosphotriester approach

Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxy...

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Veröffentlicht in:	Nucleic acids research 1988-05, Vol.16 (10), p.4607-4620
Hauptverfasser:	DE VROOM, E, BROXTERMAN, H. J. G, SLIEDREGT, L. A. J. M, VAN DER MAREL, G. A, VAN BOOM, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Drug Stability Fundamental and applied biological sciences. Psychology Indicators and Reagents Magnetic Resonance Spectroscopy Nucleic acids Nucleotides, Cyclic - chemical synthesis Oligodeoxyribonucleotides - chemical synthesis Oligoribonucleotides - chemical synthesis Phosphates Rna, ribonucleoproteins
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Beschreibung
Zusammenfassung:	Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGCG) and d(TAAAAA)] and a cyclic octadeoxyribonucleotide [d(CGTGCGTG)].
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/16.10.4607