Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings

Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings

High yielding stereo- and chemoselective Pd-catalyzed cross-couplings in THF at room temperature of alkenyl iodides and bromides with primary and secondary alkyl zinc iodides have been developed with the aid of N-methyimidazole as the key additive.

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Veröffentlicht in:Organic letters 2011-08, Vol.13 (15), p.3822-3825
Hauptverfasser: Krasovskiy, Arkady, Lipshutz, Bruce H
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Halogens - chemistry
Imidazoles - chemistry
Molecular Structure
Palladium - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:High yielding stereo- and chemoselective Pd-catalyzed cross-couplings in THF at room temperature of alkenyl iodides and bromides with primary and secondary alkyl zinc iodides have been developed with the aid of N-methyimidazole as the key additive.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201307y