Chronic Treatment with Squid Phosphatidylserine Activates Glucose Uptake and Ameliorates TMT-Induced Cognitive Deficit in Rats via Activation of Cholinergic Systems

Chronic Treatment with Squid Phosphatidylserine Activates Glucose Uptake and Ameliorates TMT-Induced Cognitive Deficit in Rats via Activation of Cholinergic Systems

The present study examined the effects of squid phosphatidylserine (Squid-PS) on the learning and memory function and the neural activity in rats with TMT-induced memory deficits. The rats were administered saline or squid derived Squid-PS (Squid-PS 50 mg kg−1, p.o.) daily for 21 days. The cognitive...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-8
Hauptverfasser: Kim, Kyung-Soo, Kim, Jin Su, Shim, Hyun Soo, Lee, Seung Youn, Park, Hyun-Jung, Shim, Insop
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholinesterase
Acetyltransferase
Alzheimer's disease
Avoidance
Behavior
Biochemistry
Brain research
Choline
Choline O-acetyltransferase
Cognitive ability
Emission analysis
Enzymatic activity
Frontal lobe
Glucose
Hippocampus
Immunohistochemistry
Laboratory animals
Latency
Learning
Membranes
Memory
Neurodegeneration
Neurons
Neurosciences
Nuclear medicine
Ovis aries
Pharmacology
Phosphatidylserine
Positron emission tomography
Psychopharmacology
Rats
Rodents
Signal transduction
Squid
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Zusammenfassung:The present study examined the effects of squid phosphatidylserine (Squid-PS) on the learning and memory function and the neural activity in rats with TMT-induced memory deficits. The rats were administered saline or squid derived Squid-PS (Squid-PS 50 mg kg−1, p.o.) daily for 21 days. The cognitive improving efficacy of Squid-PS on the amnesic rats, which was induced by TMT, was investigated by assessing the passive avoidance task and by performing choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) immunohistochemistry. 18F-Fluorodeoxyglucose and performed a positron emission tomography (PET) scan was also performed. In the passive avoidance test, the control group which were injected with TMT showed a markedly lower latency time than the non-treated normal group (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/601018