Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII

The etiology of bipolar disorder (BD) is still poorly understood, involving genetic and epigenetic mechanisms as well as environmental contributions. This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of t...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2012-06, Vol.37 (7), p.1647-1655
Hauptverfasser:	D'ADDARIO, Claudio, DELL'OSSO, Bernardo, AROSIO, Beatrice, DI FRANCESCO, Andrea, DI BENEDETTO, Manuela, ROMUALDI, Patrizia, CANDELETTI, Sanzio, MARI, Daniela, BERGAMASCHINI, Luigi, BRESOLIN, Nereo, MACCARRONE, Mauro, ALTAMURA, A. Carlo, PALAZZO, Maria Carlotta, BENATTI, Beatrice, LIETTI, Licia, CATTANEO, Elisabetta, GALIMBERTI, Daniela, FENOGLIO, Chiara, CORTINI, Francesca, SCARPINI, Elio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aged Antidepressants Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Biological and medical sciences Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - genetics Bipolar disorders Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics DNA Methylation Down-Regulation - drug effects Drugs Environmental factors Epigenetics Etiology Female Gene expression Genetic Predisposition to Disease Genotype Humans Investigations Lithium Male Medical sciences Mental disorders Mental health Middle Aged Mood Mood disorders Nervous system Neuropharmacology Original Peripheral blood mononuclear cells Pharmacology. Drug treatments Promoter Regions, Genetic Promoters Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychosis Valproic acid
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Zusammenfassung:	The etiology of bipolar disorder (BD) is still poorly understood, involving genetic and epigenetic mechanisms as well as environmental contributions. This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of the candidate genes associated with major psychoses, in peripheral blood mononuclear cells isolated from 94 patients with BD (BD I=49, BD II=45) and 52 healthy controls. A significant BDNF gene expression downregulation was observed in BD II 0.53±0.11%; P
ISSN:	0893-133X 1740-634X
DOI:	10.1038/npp.2012.10