Cell-Free Human Immunodeficiency Virus Type 1 in Breast Milk

Breast-feeding may be an important route of human immunodeficiency virus type 1 (HIV-1) vertical transmission in settings where it is routinely practiced. To define the prevalence and quantity of HIV-1 in cell-free breast milk, samples from HIV-1-seropositive women were analyzed by quantitative comp...

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Veröffentlicht in:	The Journal of infectious diseases 1998-01, Vol.177 (1), p.34-39
Hauptverfasser:	Lewis, Paul, Nduati, Ruth, Kreiss, Joan K., John, Grace C., Richardson, Barbra A., Mbori-Ngacha, Dorothy, Ndinya-Achola, Jeckoniah, Overbaugh, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS Biological and medical sciences Breast milk CD4 Lymphocyte Count CD4-CD8 Ratio Colostrum - virology DNA, Viral - analysis Epidemiology Epithelial cells Female Fundamental and applied biological sciences. Psychology HIV 1 HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV Seropositivity HIV-1 - genetics HIV-1 - isolation & purification Humans Infections Infectious Disease Transmission, Vertical Lymphocytes Major Articles Microbiology Milk, Human - virology Polymerase chain reaction Polymerase Chain Reaction - methods Prevalence RNA RNA, Viral - analysis RNA, Viral - isolation & purification Sensitivity and Specificity T lymphocytes Virology Viruses
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Beschreibung
Zusammenfassung:	Breast-feeding may be an important route of human immunodeficiency virus type 1 (HIV-1) vertical transmission in settings where it is routinely practiced. To define the prevalence and quantity of HIV-1 in cell-free breast milk, samples from HIV-1-seropositive women were analyzed by quantitative competitive reverse transcription-polymerase chain reaction (QC-RT-PCR). HIV-1 RNA was detected in 29 (39%) of 75 specimens tested. Of these 29 specimens, 16 (55%) had levels that were near the detection limit of the assay (240 copies/mL), while 6 (21%) had
ISSN:	0022-1899 1537-6613
DOI:	10.1086/513816