Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder involving diseased cardiac muscle. Bridging integrator 1 (BIN1) is a membrane-associated protein important to cardiomyocyte homeostasis and is downregulated in cardiomyopathy. We hypothesized that BIN1 could be released...

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Veröffentlicht in:	Heart rhythm 2012-06, Vol.9 (6), p.961-967
Hauptverfasser:	Hong, Ting-Ting, MD, PhD, Cogswell, Rebecca, MD, James, Cynthia A., PhD, CGC, Kang, Guson, BS, Pullinger, Clive R., PhD, Malloy, Mary J., MD, Kane, John P., MD, Wojciak, Julianne, MS, CGC, Calkins, Hugh, MD, FHRS, Scheinman, Melvin M., MD, Tseng, Zian H., MD, Ganz, Peter, MD, De Marco, Teresa, MD, Judge, Daniel P., MD, Shaw, Robin M., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - blood Adult Arrhythmias, Cardiac - blood Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - etiology Arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic Right Ventricular Dysplasia - blood Arrhythmogenic Right Ventricular Dysplasia - complications Arrhythmogenic Right Ventricular Dysplasia - physiopathology BIN1 Biomarkers - blood Bridging integrator 1 Calcium transient Cardiovascular Echocardiography Electrocardiography Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Genes, Tumor Suppressor Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - etiology Humans Male Membrane adaptor protein Middle Aged Nuclear Proteins - blood Predictive Value of Tests Prognosis Retrospective Studies Severity of Illness Index Tumor Suppressor Proteins - blood Ventricular arrhythmia
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Zusammenfassung:	Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder involving diseased cardiac muscle. Bridging integrator 1 (BIN1) is a membrane-associated protein important to cardiomyocyte homeostasis and is downregulated in cardiomyopathy. We hypothesized that BIN1 could be released into the circulation and that blood-available BIN1 can provide useful data on the cardiac status of patients whose hearts are failing secondary to ARVC. Objective To determine whether plasma BIN1 levels can be used to measure disease severity in patients with ARVC. Methods We performed a retrospective cohort study of 24 patients with ARVC. Plasma BIN1 levels were assessed for their ability to correlate with cardiac functional status and predict ventricular arrhythmias. Results Mean plasma BIN1 levels were decreased in patients with ARVC with heart failure (15 ± 7 vs 60 ± 17 in patients without heart failure, P
ISSN:	1547-5271 1556-3871
DOI:	10.1016/j.hrthm.2012.01.024