Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility

Our genome-wide association study of schizophrenia found association signals at the Kalirin gene (KALRN) and EPH receptor B1 gene (EPHB1) in a Japanese population. The importance of these synaptogenic pathway genes in schizophrenia is gaining independent supports. Although there has been growing int...

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Veröffentlicht in:	Schizophrenia bulletin 2012-05, Vol.38 (3), p.552-560
Hauptverfasser:	KUSHIMA, Itaru, NAKAMURA, Yukako, INADA, Toshiya, HASHIMOTO, Ryota, TAKEDA, Masatoshi, KAIBUCHI, Kozo, IWATA, Nakao, OZAKI, Norio, ALEKSIC, Branko, IKEDA, Masashi, ITO, Yoshihito, SHIINO, Tomoko, OKOCHI, Tomo, FUKUO, Yasuhisa, UJIKE, Hiroshi, SUZUKI, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Association analysis Biological and medical sciences Exons - genetics Female Genetic Predisposition to Disease Genome-Wide Association Study - methods Genotype Guanine Nucleotide Exchange Factors - genetics Humans Japan - epidemiology Male Medical sciences Middle Aged Mutation, Missense - genetics Protein Serine-Threonine Kinases - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptor, EphB1 - genetics Regular Risk Factors Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics
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Zusammenfassung:	Our genome-wide association study of schizophrenia found association signals at the Kalirin gene (KALRN) and EPH receptor B1 gene (EPHB1) in a Japanese population. The importance of these synaptogenic pathway genes in schizophrenia is gaining independent supports. Although there has been growing interest in rare (
ISSN:	0586-7614 1745-1701
DOI:	10.1093/schbul/sbq118