Risk Factors for ESRD in HIV-Infected Individuals: Traditional and HIV-Related Factors

Background Despite improvements in survival with human immunodeficiency virus (HIV) infection, kidney disease remains an important complication. Few studies have evaluated risk factors associated with the development of end-stage renal disease (ESRD) in HIV-infected individuals. We sought to identif...

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Veröffentlicht in:	American journal of kidney diseases 2012-05, Vol.59 (5), p.628-635
Hauptverfasser:	Jotwani, Vasantha, MD, Li, Yongmei, PhD, Grunfeld, Carl, MD, PhD, Choi, Andy I., MD, MAS, Shlipak, Michael G., MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Black People Chronic Disease chronic kidney disease Cohort Studies Diabetes Complications - complications Diabetes Complications - ethnology End-stage renal disease Female Glomerular Filtration Rate - physiology HIV Infections - complications HIV Infections - ethnology human immunodeficiency virus (HIV) Human viral diseases Humans Infectious diseases Kidney Diseases - complications Kidney Diseases - ethnology Kidney Diseases - physiopathology Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - ethnology Male Medical sciences Middle Aged Nephrology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Outcome Assessment, Health Care Proportional Hazards Models Proteinuria - complications Proteinuria - ethnology Renal failure Retrospective Studies Risk Factors Severity of Illness Index Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids White People
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Zusammenfassung:	Background Despite improvements in survival with human immunodeficiency virus (HIV) infection, kidney disease remains an important complication. Few studies have evaluated risk factors associated with the development of end-stage renal disease (ESRD) in HIV-infected individuals. We sought to identify traditional and HIV-related risk factors for ESRD in HIV-infected individuals and compare ESRD risk by estimated glomerular filtration rate (eGFR) and proteinuria levels. Study Design Retrospective cohort study. Setting & Participants 22,156 HIV-infected veterans without pre-existing ESRD receiving health care in the Veterans' Affairs medical system between 1996 and 2004. Predictors Hypertension, diabetes, cardiovascular disease, hypoalbuminemia (serum albumin
ISSN:	0272-6386 1523-6838
DOI:	10.1053/j.ajkd.2011.10.050