Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F

Histamine is a chemical mediator released from basophils or mast cells and plays an important role in allergic reactions. The formation of histamine from L-histidine is catalyzed by L-histidine decarboxylase (HDC, EC4.1.1.22) which is localized in various tissues including brain, stomach and fetal l...

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Veröffentlicht in:	Nucleic acids research 1990-10, Vol.18 (19), p.5891-5891
Hauptverfasser:	YAMAUCHI, K, SATO, R, TANNO, Y, OHKAWARA, Y, MAEYAMA, K, WATANABE, T, SATOH, K, YOSHIZAWA, M, SHIBAHARA, S, TAKISHIMA, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences DNA - genetics Fundamental and applied biological sciences. Psychology genes Genes. Genome Histidine Decarboxylase - genetics Humans leukemia Leukemia, Basophilic, Acute - enzymology Leukemia, Basophilic, Acute - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Rats Sequence Homology, Nucleic Acid Tumor Cells, Cultured
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Zusammenfassung:	Histamine is a chemical mediator released from basophils or mast cells and plays an important role in allergic reactions. The formation of histamine from L-histidine is catalyzed by L-histidine decarboxylase (HDC, EC4.1.1.22) which is localized in various tissues including brain, stomach and fetal liver as well as in basophils and mast cells. Here we present the nucleotide and deduced amino acid sequence of the cDNA coding for human HDC.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/18.19.5891