Novel avian influenza H7N3 strain outbreak, British Columbia

Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [HPAI]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate. This insertion likely occurred b...

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Veröffentlicht in:	Emerging infectious diseases 2004-12, Vol.10 (12), p.2192-2195
Hauptverfasser:	Hirst, Martin, Astell, Caroline R, Griffith, Malachi, Coughlin, Shaun M, Moksa, Michelle, Zeng, Thomas, Smailus, Duane E, Holt, Robert A, Jones, Steven, Marra, Marco A, Petric, Martin, Krajden, Mel, Lawrence, David, Mak, Annie, Chow, Ron, Skowronski, Danuta M, Tweed, S Aleina, Goh, SweeHan, Brunham, Robert C, Robinson, John, Bowes, Victoria, Sojonky, Ken, Byrne, Sean K, Li, Yan, Kobasa, Darwyn, Booth, Tim, Paetzel, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Avian influenza Avian influenza virus British Columbia - epidemiology Chickens Disease Outbreaks - veterinary Dispatch Health aspects Humans Influenza A virus - genetics Influenza A virus - pathogenicity Influenza in Birds - epidemiology Influenza in Birds - virology Models, Molecular Molecular Sequence Data Mutagenesis, Insertional Protein Conformation Sequence Alignment Viral Proteins - chemistry Viruses
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Zusammenfassung:	Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [HPAI]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate. This insertion likely occurred by recombination between the hemagglutination and matrix genes in the LPAI virus.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1012.040743