Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy

To identify transcriptional profiles predictive of the clinical benefit of cisplatin and fluorouracil (CF) chemotherapy to gastric cancer patients, endoscopic biopsy samples from 96 CF-treated metastatic gastric cancer patients were prospectively collected before therapy and analyzed using high-thro...

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Veröffentlicht in:	The pharmacogenomics journal 2012-04, Vol.12 (2), p.119-127
Hauptverfasser:	Kim, H K, Choi, I J, Kim, C G, Kim, H S, Oshima, A, Yamada, Y, Arao, T, Nishio, K, Michalowski, A, Green, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 692/699/67/1059/99 692/699/67/1504/1829 Aged Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Care and treatment Chemotherapy Clinical outcomes Female Gene Expression Genes, myc Genetic aspects Health aspects Human Genetics Humans Male Neoplasm Metastasis Oncology Original original-article Pharmacotherapy Prognosis Prospective Studies Psychopharmacology Receptor, Epidermal Growth Factor - genetics Receptor, Fibroblast Growth Factor, Type 2 - genetics Risk factors Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Survival Analysis Treatment Outcome
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Zusammenfassung:	To identify transcriptional profiles predictive of the clinical benefit of cisplatin and fluorouracil (CF) chemotherapy to gastric cancer patients, endoscopic biopsy samples from 96 CF-treated metastatic gastric cancer patients were prospectively collected before therapy and analyzed using high-throughput transcriptional profiling and array comparative genomic hybridization. Transcriptional profiling identified 917 genes that are correlated with poor patient survival after CF at P
ISSN:	1470-269X 1473-1150
DOI:	10.1038/tpj.2010.87