1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging
ABSTRACT Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift report...
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| Veröffentlicht in: | Contrast media and molecular imaging 2012-03, Vol.7 (2), p.276-279 |
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| container_title | Contrast media and molecular imaging |
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| creator | Yang, Yan Schühle, Daniel T. Dai, Guangping Alford, Jamu K. Caravan, Peter |
| description | ABSTRACT
Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd.
Simultaneous imaging of different 1H chemical shift reporters results in multiplexed detection by chemical shift imaging. Encapsulation of these reporters inside nano‐carriers yields systems capable of delivering high payloads to targets. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. |
| doi_str_mv | 10.1002/cmmi.490 |
| format | Article |
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Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd.
Simultaneous imaging of different 1H chemical shift reporters results in multiplexed detection by chemical shift imaging. Encapsulation of these reporters inside nano‐carriers yields systems capable of delivering high payloads to targets. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1002/cmmi.490</identifier><identifier>PMID: 22434641</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Chemical shift imaging ; gadolinium ; Liposomes - chemistry ; Magnetic Resonance Imaging - methods ; Molecular Probes ; multiplex ; Protons ; Signal-To-Noise Ratio ; Suspensions ; Time Factors</subject><ispartof>Contrast media and molecular imaging, 2012-03, Vol.7 (2), p.276-279</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22434641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Schühle, Daniel T.</creatorcontrib><creatorcontrib>Dai, Guangping</creatorcontrib><creatorcontrib>Alford, Jamu K.</creatorcontrib><creatorcontrib>Caravan, Peter</creatorcontrib><title>1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging</title><title>Contrast media and molecular imaging</title><addtitle>Contrast Media Mol. Imaging</addtitle><description>ABSTRACT
Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd.
Simultaneous imaging of different 1H chemical shift reporters results in multiplexed detection by chemical shift imaging. Encapsulation of these reporters inside nano‐carriers yields systems capable of delivering high payloads to targets. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals.</description><subject>Chemical shift imaging</subject><subject>gadolinium</subject><subject>Liposomes - chemistry</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Molecular Probes</subject><subject>multiplex</subject><subject>Protons</subject><subject>Signal-To-Noise Ratio</subject><subject>Suspensions</subject><subject>Time Factors</subject><issn>1555-4309</issn><issn>1555-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUlvFDEQhS0EIiEg8QuQJQ6cOthdtrt9QUIjmERKQEgsR8vtqZ526GViu5PMv48ny7CcquT6_PSqHiGvOTvmjJXv3TD4Y6HZE3LIpZSFAF493fdMH5AXMV4wJgRoeE4OylKAUIIfEsNPqOtw8M72NHa-TXSw6xGTdzRgnEY7OqQ-v_lxTTdhajDSa5862vl1RyOO0Sd_5dOWtlOgw9wnv-nx5vHLS_KstX3EVw_1iPz4_On74qQ4-7o8XXw8KzwAsEILREArZd20pbZCOGxRyLpWNW8U8NY1nDVlreuVVQqdqiun7zq5ki1UcEQ-3Otu5mbAlcMxBdubTcg-wtZM1pt_J6PvzHq6MgAlBwVZ4N2DQJguZ4zJDD467Hs74jRHo0GUVb71jnz7H3kxzWHM2xkOXFc114Jl6s3fhvZOHk-fgeIeuPY9bvdzzswuUrOL1ORIzeL8_DTXP7yPCW_2vA2_jaqgkubXl6VZLKtvqvwJhsEtu26kGA</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Yang, Yan</creator><creator>Schühle, Daniel T.</creator><creator>Dai, Guangping</creator><creator>Alford, Jamu K.</creator><creator>Caravan, Peter</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201203</creationdate><title>1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging</title><author>Yang, Yan ; Schühle, Daniel T. ; Dai, Guangping ; Alford, Jamu K. ; Caravan, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3330-94ee3ea558bf29a44cefe4588681b631fcb10b2898da66ec687c9a66ec5d5f373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Chemical shift imaging</topic><topic>gadolinium</topic><topic>Liposomes - chemistry</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Molecular Probes</topic><topic>multiplex</topic><topic>Protons</topic><topic>Signal-To-Noise Ratio</topic><topic>Suspensions</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yan</creatorcontrib><creatorcontrib>Schühle, Daniel T.</creatorcontrib><creatorcontrib>Dai, Guangping</creatorcontrib><creatorcontrib>Alford, Jamu K.</creatorcontrib><creatorcontrib>Caravan, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Contrast media and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yan</au><au>Schühle, Daniel T.</au><au>Dai, Guangping</au><au>Alford, Jamu K.</au><au>Caravan, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging</atitle><jtitle>Contrast media and molecular imaging</jtitle><addtitle>Contrast Media Mol. Imaging</addtitle><date>2012-03</date><risdate>2012</risdate><volume>7</volume><issue>2</issue><spage>276</spage><epage>279</epage><pages>276-279</pages><issn>1555-4309</issn><eissn>1555-4317</eissn><abstract>ABSTRACT
Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd.
Simultaneous imaging of different 1H chemical shift reporters results in multiplexed detection by chemical shift imaging. Encapsulation of these reporters inside nano‐carriers yields systems capable of delivering high payloads to targets. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22434641</pmid><doi>10.1002/cmmi.490</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1555-4309 |
| ispartof | Contrast media and molecular imaging, 2012-03, Vol.7 (2), p.276-279 |
| issn | 1555-4309 1555-4317 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Chemical shift imaging gadolinium Liposomes - chemistry Magnetic Resonance Imaging - methods Molecular Probes multiplex Protons Signal-To-Noise Ratio Suspensions Time Factors |
| title | 1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging |
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