1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging

ABSTRACT Proton‐based chemical shift imaging probes were encapsulated inside nano‐carriers to increase the sensivitity of the reporters. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd. Simultaneous imaging of different 1H chemical shift reporters results in multiplexed detection by chemical shift imaging. Encapsulation of these reporters inside nano‐carriers yields systems capable of delivering high payloads to targets. Co‐encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals.