Effective Use of Mass Spectrometry for Glycan and Glycopeptide Structural Analysis

Effective Use of Mass Spectrometry for Glycan and Glycopeptide Structural Analysis

Most proteins are glycosylated. Mass spectrometry methods are used for mapping glycoprotein glycosylation and detailed glycan structural determination. This technology enables precise characterization of recombinant glycoproteins in the pharmaceutical industry and academic biomedicine.

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Bibliographische Detailangaben
Veröffentlicht in:Analytical chemistry (Washington) 2012-04, Vol.84 (7), p.3040-3048
Hauptverfasser: LEYMARIE, Nancy, ZAIA, Joseph
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Analytical chemistry
Animals
Chemistry
Exact sciences and technology
Glycopeptides - chemistry
Glycopeptides - metabolism
Glycoproteins
Glycosylation
Humans
Mass spectrometry
Mass Spectrometry - methods
Molecular Sequence Data
Peptides
Pharmaceutical industry
Polysaccharides - chemistry
Polysaccharides - metabolism
Spectrometric and optical methods
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Beschreibung
Zusammenfassung:Most proteins are glycosylated. Mass spectrometry methods are used for mapping glycoprotein glycosylation and detailed glycan structural determination. This technology enables precise characterization of recombinant glycoproteins in the pharmaceutical industry and academic biomedicine.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac3000573