The many roles of TOX in the immune system

Highlights ► The TOX protein is a member of a small subfamily of HMG-box DNA binding proteins. ► The TOX protein is predicted to interact with DNA in a sequence-independent fashion. ► TOX is required for CD4 T cell lineage development in the thymus. ► TOX regulates NK cell development in the bone ma...

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Veröffentlicht in:	Current opinion in immunology 2012-04, Vol.24 (2), p.173-177
Hauptverfasser:	Aliahmad, Parinaz, Seksenyan, Akop, Kaye, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cell Differentiation High Mobility Group Proteins - immunology Humans Immune System Lymph Nodes - cytology Lymph Nodes - immunology Peyer's Patches - cytology Peyer's Patches - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	Highlights ► The TOX protein is a member of a small subfamily of HMG-box DNA binding proteins. ► The TOX protein is predicted to interact with DNA in a sequence-independent fashion. ► TOX is required for CD4 T cell lineage development in the thymus. ► TOX regulates NK cell development in the bone marrow and lymph node organogenesis.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2011.12.001