Thyroid Function and Mortality in Older Men: A Prospective Study
Context: Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality. Objective: Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a coho...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2012-03, Vol.97 (3), p.862-870 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Waring, Avantika C Harrison, Stephanie Samuels, Mary H Ensrud, Kristine E LeBlanc, Erin S Hoffman, Andrew R Orwoll, Eric Fink, Howard A Barrett-Connor, Elizabeth Bauer, Douglas C for the Osteoporotic Fractures in Men (MrOS) Study |
| description | Context:
Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality.
Objective:
Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men.
Design, Setting, and Participants:
Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH |
| doi_str_mv | 10.1210/jc.2011-2684 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3319205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>993315579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5686-2c469e6ed7c693099dc5ca5bf316e8b9b71ea57ff4a3b81c04ebee388ee960da3</originalsourceid><addsrcrecordid>eNptkc1rFDEYh4Modm29eZa5iBen5nsmHoqlWBVaWmgFbyGTecfNmk3WZKZl_3sz7FoVGggh5MnzvvkFoVcEHxNK8PuVPaaYkJrKlj9BC6K4qBuimqdogTEltWro9wP0IucVxoRzwZ6jA0opa5mSC_TxdrlN0fXV-RTs6GKoTOiry5hG4924rVyornwPqbqE8KE6ra5TzBso5B1UN-PUb4_Qs8H4DC_36yH6dv7p9uxLfXH1-evZ6UVthWxlTS2XCiT0jZWKYaV6K6wR3cCIhLZTXUPAiGYYuGFdSyzm0AGwtgVQEveGHaKTnXczdWvoLYQxGa83ya1N2uponP7_JLil_hHvNGNEUSyK4O1ekOKvCfKo1y5b8N4EiFPWShVSiEYV8t2OtOWxOcHwUIVgPWeuV1bPmes584K__rezB_hPyAV4swdMtsYPyQTr8l9OSIx5M4v4jruPfoSUf_rpHpJegvHjUuMyuGzaulSmmJVdXSad9Wx3DUIfbXIBNgly1qs4pVC-5PGufwOw8KsB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>993315579</pqid></control><display><type>article</type><title>Thyroid Function and Mortality in Older Men: A Prospective Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Waring, Avantika C ; Harrison, Stephanie ; Samuels, Mary H ; Ensrud, Kristine E ; LeBlanc, Erin S ; Hoffman, Andrew R ; Orwoll, Eric ; Fink, Howard A ; Barrett-Connor, Elizabeth ; Bauer, Douglas C ; for the Osteoporotic Fractures in Men (MrOS) Study</creator><creatorcontrib>Waring, Avantika C ; Harrison, Stephanie ; Samuels, Mary H ; Ensrud, Kristine E ; LeBlanc, Erin S ; Hoffman, Andrew R ; Orwoll, Eric ; Fink, Howard A ; Barrett-Connor, Elizabeth ; Bauer, Douglas C ; for the Osteoporotic Fractures in Men (MrOS) Study ; Osteoporotic Fractures in Men (MrOS) Study ; for the Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><description>Context:
Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality.
Objective:
Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men.
Design, Setting, and Participants:
Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH <10 mIU/liter; and subclinical hypothyroid, TSH ≥10 mIU/liter.)
Main Outcome Measure:
Total mortality, cardiovascular (CV) and cancer deaths were confirmed by review of death certificates.
Results:
There were 432 deaths over a mean follow-up of 8.3 yr. In fully adjusted models, there was no association between baseline TSH and any death [relative hazard (RH) = 1.01 per mIU/liter, 95% confidence interval (CI) = 0.95–1.06], CV death (RH = 1.05 per mIU/liter, 95% CI 0.96–1.15), or cancer death (RH = 0.96 per mIU/liter, 95% CI = 0.85–1.07). There was also no statistically significant association between thyroid function category and total or cause-specific mortality, but few men (n = 8) had subclinical hypothyroidism with TSH levels of 10 mIU/liter or higher.
Conclusions:
A single measurement of thyroid function did not predict total or cause-specific mortality in this cohort. These data support neither a beneficial nor a detrimental effect of subclinical thyroid dysfunction in older men.
Summary:
Subclinical thyroid dysfunction is not associated with an increased risk of all-cause or CV mortality in older men.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2011-2684</identifier><identifier>PMID: 22238396</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Endocrine Care ; Endocrinopathies ; Feeding. Feeding behavior ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Neoplasms - mortality ; Neoplasms - physiopathology ; Thyroid Diseases - mortality ; Thyroid Diseases - physiopathology ; Thyroid Function Tests ; Thyroid Gland - physiopathology ; Thyrotropin - blood ; Thyroxine - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2012-03, Vol.97 (3), p.862-870</ispartof><rights>Copyright © 2012 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 by The Endocrine Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5686-2c469e6ed7c693099dc5ca5bf316e8b9b71ea57ff4a3b81c04ebee388ee960da3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25600474$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22238396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waring, Avantika C</creatorcontrib><creatorcontrib>Harrison, Stephanie</creatorcontrib><creatorcontrib>Samuels, Mary H</creatorcontrib><creatorcontrib>Ensrud, Kristine E</creatorcontrib><creatorcontrib>LeBlanc, Erin S</creatorcontrib><creatorcontrib>Hoffman, Andrew R</creatorcontrib><creatorcontrib>Orwoll, Eric</creatorcontrib><creatorcontrib>Fink, Howard A</creatorcontrib><creatorcontrib>Barrett-Connor, Elizabeth</creatorcontrib><creatorcontrib>Bauer, Douglas C</creatorcontrib><creatorcontrib>for the Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><creatorcontrib>for the Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><title>Thyroid Function and Mortality in Older Men: A Prospective Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality.
Objective:
Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men.
Design, Setting, and Participants:
Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH <10 mIU/liter; and subclinical hypothyroid, TSH ≥10 mIU/liter.)
Main Outcome Measure:
Total mortality, cardiovascular (CV) and cancer deaths were confirmed by review of death certificates.
Results:
There were 432 deaths over a mean follow-up of 8.3 yr. In fully adjusted models, there was no association between baseline TSH and any death [relative hazard (RH) = 1.01 per mIU/liter, 95% confidence interval (CI) = 0.95–1.06], CV death (RH = 1.05 per mIU/liter, 95% CI 0.96–1.15), or cancer death (RH = 0.96 per mIU/liter, 95% CI = 0.85–1.07). There was also no statistically significant association between thyroid function category and total or cause-specific mortality, but few men (n = 8) had subclinical hypothyroidism with TSH levels of 10 mIU/liter or higher.
Conclusions:
A single measurement of thyroid function did not predict total or cause-specific mortality in this cohort. These data support neither a beneficial nor a detrimental effect of subclinical thyroid dysfunction in older men.
Summary:
Subclinical thyroid dysfunction is not associated with an increased risk of all-cause or CV mortality in older men.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Endocrine Care</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - physiopathology</subject><subject>Thyroid Diseases - mortality</subject><subject>Thyroid Diseases - physiopathology</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1rFDEYh4Modm29eZa5iBen5nsmHoqlWBVaWmgFbyGTecfNmk3WZKZl_3sz7FoVGggh5MnzvvkFoVcEHxNK8PuVPaaYkJrKlj9BC6K4qBuimqdogTEltWro9wP0IucVxoRzwZ6jA0opa5mSC_TxdrlN0fXV-RTs6GKoTOiry5hG4924rVyornwPqbqE8KE6ra5TzBso5B1UN-PUb4_Qs8H4DC_36yH6dv7p9uxLfXH1-evZ6UVthWxlTS2XCiT0jZWKYaV6K6wR3cCIhLZTXUPAiGYYuGFdSyzm0AGwtgVQEveGHaKTnXczdWvoLYQxGa83ya1N2uponP7_JLil_hHvNGNEUSyK4O1ekOKvCfKo1y5b8N4EiFPWShVSiEYV8t2OtOWxOcHwUIVgPWeuV1bPmes584K__rezB_hPyAV4swdMtsYPyQTr8l9OSIx5M4v4jruPfoSUf_rpHpJegvHjUuMyuGzaulSmmJVdXSad9Wx3DUIfbXIBNgly1qs4pVC-5PGufwOw8KsB</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Waring, Avantika C</creator><creator>Harrison, Stephanie</creator><creator>Samuels, Mary H</creator><creator>Ensrud, Kristine E</creator><creator>LeBlanc, Erin S</creator><creator>Hoffman, Andrew R</creator><creator>Orwoll, Eric</creator><creator>Fink, Howard A</creator><creator>Barrett-Connor, Elizabeth</creator><creator>Bauer, Douglas C</creator><creator>for the Osteoporotic Fractures in Men (MrOS) Study</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201203</creationdate><title>Thyroid Function and Mortality in Older Men: A Prospective Study</title><author>Waring, Avantika C ; Harrison, Stephanie ; Samuels, Mary H ; Ensrud, Kristine E ; LeBlanc, Erin S ; Hoffman, Andrew R ; Orwoll, Eric ; Fink, Howard A ; Barrett-Connor, Elizabeth ; Bauer, Douglas C ; for the Osteoporotic Fractures in Men (MrOS) Study</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5686-2c469e6ed7c693099dc5ca5bf316e8b9b71ea57ff4a3b81c04ebee388ee960da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Endocrine Care</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - physiopathology</topic><topic>Thyroid Diseases - mortality</topic><topic>Thyroid Diseases - physiopathology</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waring, Avantika C</creatorcontrib><creatorcontrib>Harrison, Stephanie</creatorcontrib><creatorcontrib>Samuels, Mary H</creatorcontrib><creatorcontrib>Ensrud, Kristine E</creatorcontrib><creatorcontrib>LeBlanc, Erin S</creatorcontrib><creatorcontrib>Hoffman, Andrew R</creatorcontrib><creatorcontrib>Orwoll, Eric</creatorcontrib><creatorcontrib>Fink, Howard A</creatorcontrib><creatorcontrib>Barrett-Connor, Elizabeth</creatorcontrib><creatorcontrib>Bauer, Douglas C</creatorcontrib><creatorcontrib>for the Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><creatorcontrib>for the Osteoporotic Fractures in Men (MrOS) Study</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waring, Avantika C</au><au>Harrison, Stephanie</au><au>Samuels, Mary H</au><au>Ensrud, Kristine E</au><au>LeBlanc, Erin S</au><au>Hoffman, Andrew R</au><au>Orwoll, Eric</au><au>Fink, Howard A</au><au>Barrett-Connor, Elizabeth</au><au>Bauer, Douglas C</au><au>for the Osteoporotic Fractures in Men (MrOS) Study</au><aucorp>Osteoporotic Fractures in Men (MrOS) Study</aucorp><aucorp>for the Osteoporotic Fractures in Men (MrOS) Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid Function and Mortality in Older Men: A Prospective Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2012-03</date><risdate>2012</risdate><volume>97</volume><issue>3</issue><spage>862</spage><epage>870</epage><pages>862-870</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality.
Objective:
Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men.
Design, Setting, and Participants:
Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH <10 mIU/liter; and subclinical hypothyroid, TSH ≥10 mIU/liter.)
Main Outcome Measure:
Total mortality, cardiovascular (CV) and cancer deaths were confirmed by review of death certificates.
Results:
There were 432 deaths over a mean follow-up of 8.3 yr. In fully adjusted models, there was no association between baseline TSH and any death [relative hazard (RH) = 1.01 per mIU/liter, 95% confidence interval (CI) = 0.95–1.06], CV death (RH = 1.05 per mIU/liter, 95% CI 0.96–1.15), or cancer death (RH = 0.96 per mIU/liter, 95% CI = 0.85–1.07). There was also no statistically significant association between thyroid function category and total or cause-specific mortality, but few men (n = 8) had subclinical hypothyroidism with TSH levels of 10 mIU/liter or higher.
Conclusions:
A single measurement of thyroid function did not predict total or cause-specific mortality in this cohort. These data support neither a beneficial nor a detrimental effect of subclinical thyroid dysfunction in older men.
Summary:
Subclinical thyroid dysfunction is not associated with an increased risk of all-cause or CV mortality in older men.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>22238396</pmid><doi>10.1210/jc.2011-2684</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2012-03, Vol.97 (3), p.862-870 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3319205 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Cardiovascular Diseases - mortality Cardiovascular Diseases - physiopathology Endocrine Care Endocrinopathies Feeding. Feeding behavior Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Neoplasms - mortality Neoplasms - physiopathology Thyroid Diseases - mortality Thyroid Diseases - physiopathology Thyroid Function Tests Thyroid Gland - physiopathology Thyrotropin - blood Thyroxine - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Thyroid Function and Mortality in Older Men: A Prospective Study |
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