Thyroid Function and Mortality in Older Men: A Prospective Study

Context: Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality. Objective: Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a coho...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2012-03, Vol.97 (3), p.862-870
Hauptverfasser:	Waring, Avantika C, Harrison, Stephanie, Samuels, Mary H, Ensrud, Kristine E, LeBlanc, Erin S, Hoffman, Andrew R, Orwoll, Eric, Fink, Howard A, Barrett-Connor, Elizabeth, Bauer, Douglas C, for the Osteoporotic Fractures in Men (MrOS) Study
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Cardiovascular Diseases - mortality Cardiovascular Diseases - physiopathology Endocrine Care Endocrinopathies Feeding. Feeding behavior Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Neoplasms - mortality Neoplasms - physiopathology Thyroid Diseases - mortality Thyroid Diseases - physiopathology Thyroid Function Tests Thyroid Gland - physiopathology Thyrotropin - blood Thyroxine - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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Zusammenfassung:	Context: Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality. Objective: Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men. Design, Setting, and Participants: Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2011-2684