Recurrent severe exacerbations in early life and reduced lung function at school age

[...]data from the Tucson Children's Respiratory Study suggest that abnormalities in lung function might not be present during the first year of life but develop during early childhood in children with persistent wheezing.3 Our findings highlight the importance of close follow-up for children with histories of severe exacerbations during early life and suggest that preventing additional severe wheezing episodes could affect subsequent morbidity caused by loss of lung function. [...]novel strategies for the prevention of wheezing exacerbations, particularly in preschool children, are sorely needed.