Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

Over the past 20 years, high-risk human papilloma-virus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a sma...

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Veröffentlicht in:	Journal of Dental Research 2009-04, Vol.88 (4), p.300-306
Hauptverfasser:	Hennessey, P.T., Westra, W.H., Califano, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphapapillomavirus - pathogenicity Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cell Transformation, Neoplastic Critical Reviews in Oral Biology & Medicine Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Humans Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - virology Papillomavirus Infections - complications Papillomavirus Infections - pathology Papillomavirus Infections - virology Risk Factors Survival Rate
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Beschreibung
Zusammenfassung:	Over the past 20 years, high-risk human papilloma-virus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. In this review, we summarize what is currently known about the biology of HPV, the mechanisms by which it effects malignant transformation, and the potential impact of HPV status on the clinical management of persons with head and neck cancer.
ISSN:	0022-0345 1544-0591
DOI:	10.1177/0022034509333371