Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors

Dear Editor, Parkinson＇s disease （PD） is a neurodegenerative disease that afflicts around 1% of the population over age 65 [1]. One of the pathological hallmarks of PD is the degeneration of dopaminergic （DA） neurons at midbrain and the relatively focal lesion feature of PD makes cell replacement a promising approach for treating the dis- ease [2].