Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells

Dear Editor, The in vitro propagation （IVP） of animal spermatogonial stem cells （SSCs） provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy. The IVP of SSCs is reported to be promoted by exogenous growth factors, among which...

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Veröffentlicht in:	Cell research 2012-04, Vol.22 (4), p.773-776
Hauptverfasser:	Zhang, Yan, Wang, Si, Wang, Xiuxia, Liao, Shangying, Wu, Yujian, Han, Chunsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2434/1822 631/532 631/80/86 Animals Biomedical and Life Sciences Cell Biology Cell Proliferation - drug effects Cell Survival - genetics Cells, Cultured Feeder Cells - metabolism Fibroblast Growth Factor 2 - biosynthesis Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation Gene Knockdown Techniques Letter to the Editor Life Sciences Male MAP Kinase Signaling System - genetics Mice Protein Isoforms - biosynthesis Protein Isoforms - metabolism Pyrroles - pharmacology Spermatogenesis - genetics Spermatogonia - cytology Spermatogonia - metabolism SSCS Stem cells Stem Cells - cytology Stem Cells - metabolism 内源性培养增殖小鼠精原干细胞精子发生胶质细胞源性神经营养因子
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Zusammenfassung:	Dear Editor, The in vitro propagation （IVP） of animal spermatogonial stem cells （SSCs） provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy. The IVP of SSCs is reported to be promoted by exogenous growth factors, among which the glial cell-derived neurotrophic factor （GDNF） has been recognized as the single essential one [1, 2]. FGF2,
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2012.17