The abundance of deleterious polymorphisms in humans
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in h...
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| Veröffentlicht in: | Genetics (Austin) 2012-04, Vol.190 (4), p.1579-1583 |
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| container_title | Genetics (Austin) |
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| creator | Subramanian, Sankar |
| description | Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans. |
| doi_str_mv | 10.1534/genetics.111.137893 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1943-2631 |
| ispartof | Genetics (Austin), 2012-04, Vol.190 (4), p.1579-1583 |
| issn | 1943-2631 0016-6731 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3316666 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptation, Biological Amino Acid Substitution Ethnic Groups - genetics Evolution, Molecular Gene Frequency Genetics, Population Genome, Human Genomes Humans Phylogeny Polymorphism Polymorphism, Single Nucleotide Population Studies Time Factors |
| title | The abundance of deleterious polymorphisms in humans |
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