The abundance of deleterious polymorphisms in humans

The abundance of deleterious polymorphisms in humans

Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in h...

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Veröffentlicht in:Genetics (Austin) 2012-04, Vol.190 (4), p.1579-1583
1. Verfasser: Subramanian, Sankar
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Biological
Amino Acid Substitution
Ethnic Groups - genetics
Evolution, Molecular
Gene Frequency
Genetics, Population
Genome, Human
Genomes
Humans
Phylogeny
Polymorphism
Polymorphism, Single Nucleotide
Population
Studies
Time Factors
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Beschreibung
Zusammenfassung:Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.111.137893