A moderately frequent HindIII polymorphism at the human NGFR locus (17q12→17q22)

The clone Lambda6 contains human NGFR sequences cloned in the vector CH28. HindIII (AAGCTT) reveals allelic bands of 13 kb and 8.3+4.7 kb with a constant band of 8.8 kb. The NGFR locus has been assigned to 17q12->17q22 with somatic cell hybrid analysis and in situ hybridization. The HindIII site...

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Veröffentlicht in:	Nucleic acids research 1989-01, Vol.17 (2), p.825-825
Hauptverfasser:	WRIGHT, E. C, FAIN, P. R, BARKER, D. F, CHAO, M. V
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry BASIC BIOLOGICAL SCIENCES Biological and medical sciences Chromosome Mapping CHROMOSOMES Chromosomes, Human, Pair 17 CLONING Deoxyribonuclease HindIII DNA DNA HYBRIDIZATION DNA-CLONING Fundamental and applied biological sciences. Psychology Genes. Genome GENETIC MAPPING HETEROCHROMOSOMES HUMAN POPULATIONS Humans HYBRIDIZATION MAPPING Molecular and cellular biology Molecular genetics Nerve Growth Factors - metabolism NUCLEIC ACIDS ORGANIC COMPOUNDS Polymorphism, Genetic Polymorphism, Restriction Fragment Length POPULATIONS Receptors, Cell Surface - genetics Receptors, Nerve Growth Factor RECOMBINANT DNA RFLPS
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Zusammenfassung:	The clone Lambda6 contains human NGFR sequences cloned in the vector CH28. HindIII (AAGCTT) reveals allelic bands of 13 kb and 8.3+4.7 kb with a constant band of 8.8 kb. The NGFR locus has been assigned to 17q12->17q22 with somatic cell hybrid analysis and in situ hybridization. The HindIII site polymorphism shows tight genetic linkage to HOX2 and other 17q markers. No significant deviation from Hardy-Weinberg equilibrium has been observed. No departure from Mendelian expectations in 39 offspring of segregating matings was found.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/17.2.825