CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals
Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L c...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2012-04, Vol.30 (17), p.2768-2777 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2777 |
|---|---|
| container_issue | 17 |
| container_start_page | 2768 |
| container_title | Vaccine |
| container_volume | 30 |
| creator | Auten, Matthew W Huang, Weitao Dai, Guixiang Ramsay, Alistair J |
| description | Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L cannot restore vaccine-induced immunity in a CD4-ablated mouse model. ► CD40L enhances vaccine-induced immunity in a CD4-depleted mouse model. |
| doi_str_mv | 10.1016/j.vaccine.2012.02.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3313012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0264410X12001910</els_id><sourcerecordid>3477163771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-6e14fd22b9d43c8a5cf5e26bc0541f9a338a047206d58f29d6230f6ad59d292b3</originalsourceid><addsrcrecordid>eNqFkluLEzEUgAdR3Lr6E9QBHxRkai6TNHlZkXqFBR92F3wLaZLpps4k3WSm0H_vCa2r7oMLgTzkO1_OraqeYzTHCPN3m_lOG-ODmxOEyRyVgx5UMywWtCEMi4fVDBHeNi1GP06qJzlvEEKMYvm4OiGEtpIROqum5ccW1b1f62BrF651MC7XfhimENcueOPHfR27eufMGFOz0tnZ-vgzcOGImjhs3ejCWBcPON_Wl7VxfV9b14GkvPhg_c7bSff5afWog8s9O96n1dXnT5fLr8359y_flh_OG8MlHhvucNtZQlbSttQIzUzHHOErg1iLO6kpFRq1C4K4ZaIj0nJCUce1ZdISSVb0tDo7eLfTanDWQBpJ92qb_KDTXkXt1b8vwV-rddwpSjGFtoLg9VGQ4s3k8qgGn0tdOrg4ZSVbITHBLQXyzX9JzBeCgVby-1GEwUmZkIC-uoNu4pQC9AyEWEiGEC1ZsgNlUsw5ue62QoyKjauNOs5MlW1RqBwEcS_-bs9t1O_1AODlAeh0VHqdfFZXF2CAb3FLhBRAvD8QDsa48y6pXKZtnPUJVkbZ6O9N4uyOwfQeFk_3P93e5T_1qgwB6qIsddlpTCAJiRH9BcMx8Og</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1618950032</pqid></control><display><type>article</type><title>CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Auten, Matthew W ; Huang, Weitao ; Dai, Guixiang ; Ramsay, Alistair J</creator><creatorcontrib>Auten, Matthew W ; Huang, Weitao ; Dai, Guixiang ; Ramsay, Alistair J</creatorcontrib><description>Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L cannot restore vaccine-induced immunity in a CD4-ablated mouse model. ► CD40L enhances vaccine-induced immunity in a CD4-depleted mouse model.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2012.02.020</identifier><identifier>PMID: 22349523</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Acyltransferases - genetics ; Acyltransferases - immunology ; Adenoviridae - genetics ; Adjuvanticity ; Adjuvants ; Allergy and Immunology ; Animals ; Antigen 85B ; Antigens ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; Bacterial Proteins - genetics ; Bacterial Proteins - immunology ; Bone marrow ; CD154 antigen ; CD4 antigen ; CD4-positive T-lymphocytes ; CD4-Positive T-Lymphocytes - immunology ; CD40 antigen ; CD40 ligand ; CD40 Ligand - genetics ; CD40L protein ; CD8 antigen ; CD8-positive T-lymphocytes ; Expression vectors ; Female ; Gene Expression ; Genetic Vectors - administration & dosage ; immune response ; Immune system ; Immunization ; Immunocompetence ; Immunocompromised Host ; Immunodeficiency ; Immunogenicity ; Lung ; Lymphocyte Depletion ; Lymphocytes T ; Mice ; Mice, Inbred BALB C ; Mucosa ; Mycobacterium ; Pathogens ; Plasmids ; Plasmids - administration & dosage ; Plasmids - genetics ; Respiratory Mucosa - immunology ; Tuberculosis ; Tumor necrosis factor ; tumor necrosis factors ; Vaccine adjuvant ; Vaccines ; Vaccines, DNA - administration & dosage ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology</subject><ispartof>Vaccine, 2012-04, Vol.30 (17), p.2768-2777</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 5, 2012</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-6e14fd22b9d43c8a5cf5e26bc0541f9a338a047206d58f29d6230f6ad59d292b3</citedby><cites>FETCH-LOGICAL-c691t-6e14fd22b9d43c8a5cf5e26bc0541f9a338a047206d58f29d6230f6ad59d292b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X12001910$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22349523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auten, Matthew W</creatorcontrib><creatorcontrib>Huang, Weitao</creatorcontrib><creatorcontrib>Dai, Guixiang</creatorcontrib><creatorcontrib>Ramsay, Alistair J</creatorcontrib><title>CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L cannot restore vaccine-induced immunity in a CD4-ablated mouse model. ► CD40L enhances vaccine-induced immunity in a CD4-depleted mouse model.</description><subject>Acyltransferases - genetics</subject><subject>Acyltransferases - immunology</subject><subject>Adenoviridae - genetics</subject><subject>Adjuvanticity</subject><subject>Adjuvants</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigen 85B</subject><subject>Antigens</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - immunology</subject><subject>Bone marrow</subject><subject>CD154 antigen</subject><subject>CD4 antigen</subject><subject>CD4-positive T-lymphocytes</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD40 antigen</subject><subject>CD40 ligand</subject><subject>CD40 Ligand - genetics</subject><subject>CD40L protein</subject><subject>CD8 antigen</subject><subject>CD8-positive T-lymphocytes</subject><subject>Expression vectors</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Genetic Vectors - administration & dosage</subject><subject>immune response</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Immunocompetence</subject><subject>Immunocompromised Host</subject><subject>Immunodeficiency</subject><subject>Immunogenicity</subject><subject>Lung</subject><subject>Lymphocyte Depletion</subject><subject>Lymphocytes T</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mucosa</subject><subject>Mycobacterium</subject><subject>Pathogens</subject><subject>Plasmids</subject><subject>Plasmids - administration & dosage</subject><subject>Plasmids - genetics</subject><subject>Respiratory Mucosa - immunology</subject><subject>Tuberculosis</subject><subject>Tumor necrosis factor</subject><subject>tumor necrosis factors</subject><subject>Vaccine adjuvant</subject><subject>Vaccines</subject><subject>Vaccines, DNA - administration & dosage</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkluLEzEUgAdR3Lr6E9QBHxRkai6TNHlZkXqFBR92F3wLaZLpps4k3WSm0H_vCa2r7oMLgTzkO1_OraqeYzTHCPN3m_lOG-ODmxOEyRyVgx5UMywWtCEMi4fVDBHeNi1GP06qJzlvEEKMYvm4OiGEtpIROqum5ccW1b1f62BrF651MC7XfhimENcueOPHfR27eufMGFOz0tnZ-vgzcOGImjhs3ejCWBcPON_Wl7VxfV9b14GkvPhg_c7bSff5afWog8s9O96n1dXnT5fLr8359y_flh_OG8MlHhvucNtZQlbSttQIzUzHHOErg1iLO6kpFRq1C4K4ZaIj0nJCUce1ZdISSVb0tDo7eLfTanDWQBpJ92qb_KDTXkXt1b8vwV-rddwpSjGFtoLg9VGQ4s3k8qgGn0tdOrg4ZSVbITHBLQXyzX9JzBeCgVby-1GEwUmZkIC-uoNu4pQC9AyEWEiGEC1ZsgNlUsw5ue62QoyKjauNOs5MlW1RqBwEcS_-bs9t1O_1AODlAeh0VHqdfFZXF2CAb3FLhBRAvD8QDsa48y6pXKZtnPUJVkbZ6O9N4uyOwfQeFk_3P93e5T_1qgwB6qIsddlpTCAJiRH9BcMx8Og</recordid><startdate>20120405</startdate><enddate>20120405</enddate><creator>Auten, Matthew W</creator><creator>Huang, Weitao</creator><creator>Dai, Guixiang</creator><creator>Ramsay, Alistair J</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120405</creationdate><title>CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals</title><author>Auten, Matthew W ; Huang, Weitao ; Dai, Guixiang ; Ramsay, Alistair J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-6e14fd22b9d43c8a5cf5e26bc0541f9a338a047206d58f29d6230f6ad59d292b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acyltransferases - genetics</topic><topic>Acyltransferases - immunology</topic><topic>Adenoviridae - genetics</topic><topic>Adjuvanticity</topic><topic>Adjuvants</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigen 85B</topic><topic>Antigens</topic><topic>Antigens, Bacterial - genetics</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - immunology</topic><topic>Bone marrow</topic><topic>CD154 antigen</topic><topic>CD4 antigen</topic><topic>CD4-positive T-lymphocytes</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD40 antigen</topic><topic>CD40 ligand</topic><topic>CD40 Ligand - genetics</topic><topic>CD40L protein</topic><topic>CD8 antigen</topic><topic>CD8-positive T-lymphocytes</topic><topic>Expression vectors</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Genetic Vectors - administration & dosage</topic><topic>immune response</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Immunocompetence</topic><topic>Immunocompromised Host</topic><topic>Immunodeficiency</topic><topic>Immunogenicity</topic><topic>Lung</topic><topic>Lymphocyte Depletion</topic><topic>Lymphocytes T</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mucosa</topic><topic>Mycobacterium</topic><topic>Pathogens</topic><topic>Plasmids</topic><topic>Plasmids - administration & dosage</topic><topic>Plasmids - genetics</topic><topic>Respiratory Mucosa - immunology</topic><topic>Tuberculosis</topic><topic>Tumor necrosis factor</topic><topic>tumor necrosis factors</topic><topic>Vaccine adjuvant</topic><topic>Vaccines</topic><topic>Vaccines, DNA - administration & dosage</topic><topic>Vaccines, DNA - genetics</topic><topic>Vaccines, DNA - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auten, Matthew W</creatorcontrib><creatorcontrib>Huang, Weitao</creatorcontrib><creatorcontrib>Dai, Guixiang</creatorcontrib><creatorcontrib>Ramsay, Alistair J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auten, Matthew W</au><au>Huang, Weitao</au><au>Dai, Guixiang</au><au>Ramsay, Alistair J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2012-04-05</date><risdate>2012</risdate><volume>30</volume><issue>17</issue><spage>2768</spage><epage>2777</epage><pages>2768-2777</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L cannot restore vaccine-induced immunity in a CD4-ablated mouse model. ► CD40L enhances vaccine-induced immunity in a CD4-depleted mouse model.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>22349523</pmid><doi>10.1016/j.vaccine.2012.02.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2012-04, Vol.30 (17), p.2768-2777 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3313012 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acyltransferases - genetics Acyltransferases - immunology Adenoviridae - genetics Adjuvanticity Adjuvants Allergy and Immunology Animals Antigen 85B Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology Bone marrow CD154 antigen CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology CD40 antigen CD40 ligand CD40 Ligand - genetics CD40L protein CD8 antigen CD8-positive T-lymphocytes Expression vectors Female Gene Expression Genetic Vectors - administration & dosage immune response Immune system Immunization Immunocompetence Immunocompromised Host Immunodeficiency Immunogenicity Lung Lymphocyte Depletion Lymphocytes T Mice Mice, Inbred BALB C Mucosa Mycobacterium Pathogens Plasmids Plasmids - administration & dosage Plasmids - genetics Respiratory Mucosa - immunology Tuberculosis Tumor necrosis factor tumor necrosis factors Vaccine adjuvant Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology |
| title | CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T06%3A07%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD40%20ligand%20enhances%20immunogenicity%20of%20vector-based%20vaccines%20in%20immunocompetent%20and%20CD4+%20T%20cell%20deficient%20individuals&rft.jtitle=Vaccine&rft.au=Auten,%20Matthew%20W&rft.date=2012-04-05&rft.volume=30&rft.issue=17&rft.spage=2768&rft.epage=2777&rft.pages=2768-2777&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2012.02.020&rft_dat=%3Cproquest_pubme%3E3477163771%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1618950032&rft_id=info:pmid/22349523&rft_els_id=1_s2_0_S0264410X12001910&rfr_iscdi=true |