CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals

Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L c...

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Veröffentlicht in:	Vaccine 2012-04, Vol.30 (17), p.2768-2777
Hauptverfasser:	Auten, Matthew W, Huang, Weitao, Dai, Guixiang, Ramsay, Alistair J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - immunology Adenoviridae - genetics Adjuvanticity Adjuvants Allergy and Immunology Animals Antigen 85B Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Proteins - genetics Bacterial Proteins - immunology Bone marrow CD154 antigen CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology CD40 antigen CD40 ligand CD40 Ligand - genetics CD40L protein CD8 antigen CD8-positive T-lymphocytes Expression vectors Female Gene Expression Genetic Vectors - administration & dosage immune response Immune system Immunization Immunocompetence Immunocompromised Host Immunodeficiency Immunogenicity Lung Lymphocyte Depletion Lymphocytes T Mice Mice, Inbred BALB C Mucosa Mycobacterium Pathogens Plasmids Plasmids - administration & dosage Plasmids - genetics Respiratory Mucosa - immunology Tuberculosis Tumor necrosis factor tumor necrosis factors Vaccine adjuvant Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:	Highlights ► Vector-expressed CD40L functions as a vaccine adjuvant for circulating and lung mucosal T cell responses. ► CD40L adjuvant activity in booster immunizations is route-dependent. ► CD40L adjuvant activity enhances the magnitude of vaccine-induced polyfunctional T cell responses. ► CD40L cannot restore vaccine-induced immunity in a CD4-ablated mouse model. ► CD40L enhances vaccine-induced immunity in a CD4-depleted mouse model.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.02.020