An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs

An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs

The skins of Madagascar poison frogs (Mantella) and certain Neotropical poison frogs (Epipedobates, Dendrobates) secrete the new bile acid tauromantellic acid (1), which was found in both wild-caught and captive-born frogs. This is the first molecule of endogenous origin detected in skin secretions...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2012-03, Vol.75 (3), p.473-478
Hauptverfasser: Clark, Valerie C, Harinantenaina, Liva, Zeller, Martin, Ronto, William, Rocca, James, Dossey, Aaron T, Rakotondravony, Daniel, Kingston, David G. I, Shaw, Chris
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Animals
Anura
Bile Acids and Salts - analysis
Dietary Sucrose - analysis
Madagascar
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Skin - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The skins of Madagascar poison frogs (Mantella) and certain Neotropical poison frogs (Epipedobates, Dendrobates) secrete the new bile acid tauromantellic acid (1), which was found in both wild-caught and captive-born frogs. This is the first molecule of endogenous origin detected in skin secretions from these taxa. Sucrose was also detected in secretions from wild-caught Mantella but not in captive-born frogs, suggesting a dietary origin.
ISSN:0163-3864
1520-6025
DOI:10.1021/np200963r