Ure(k)a! Sirtuins Regulate Mitochondria

Ure(k)a! Sirtuins Regulate Mitochondria

Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which med...

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Veröffentlicht in:Cell 2009-05, Vol.137 (3), p.404-406
Hauptverfasser: Hallows, William C, Smith, Brian C, Lee, Susan, Denu, John M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbamoyl-Phosphate Synthase (Ammonia) - metabolism
Enzyme Activation
Humans
Mice
Mitochondria - metabolism
Mitochondrial Proteins - metabolism
Sirtuins - metabolism
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Zusammenfassung:Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.04.036