Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101

Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically rela...

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Veröffentlicht in:Emerging infectious diseases 2012-01, Vol.18 (1), p.86-90
Hauptverfasser: Dannaoui, Eric, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Grenouillet, Frederic, Cassaing, Sophie, Baixench, Marie-Therese, Bretagne, Stephane, Dromer, Frangoise, Lortholary, Olivier
Format: Artikel
Sprache:eng
Schlagworte:
Dispatch
Genetic aspects
Health aspects
Mycoses
Pharmaceutical industry
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Zusammenfassung:We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1801.110556