Rat brains also have a default mode network

The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonh...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2012-03, Vol.109 (10), p.3979-3984
Hauptverfasser: Lu, Hanbing, Zou, Qihong, Gu, Hong, Raichle, Marcus E, Stein, Elliot A, Yang, Yihong
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Sprache:eng
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Zusammenfassung:The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1200506109