Abatacept and Sodium Thiosulfate for Treatment of Recalcitrant Juvenile Dermatomyositis Complicated by Ulceration and Calcinosis

We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased co...

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Veröffentlicht in:	The Journal of pediatrics 2012-03, Vol.160 (3), p.520-522
Hauptverfasser:	Arabshahi, Bita, MD, Silverman, Robert A., MD, Jones, Olcay Y., MD, PhD, Rider, Lisa G., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Adolescent Anti-Inflammatory Agents - administration & dosage Antioxidants - administration & dosage Biological and medical sciences calcinosis Calcinosis - complications Chelating Agents - administration & dosage dermatomyositis Dermatomyositis - complications Dermatomyositis - drug therapy Dermatomyositis - pathology Drug Therapy, Combination Female General aspects Humans Immunoconjugates - administration & dosage Immunosuppressive Agents - administration & dosage inflammation Medical sciences muscles patients Pediatrics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Ulcer - complications sodium therapeutics Thiosulfates - administration & dosage
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Zusammenfassung:	We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2011.11.057