Metalloregulation of Gram-positive pathogen physiology

Highlights ► Pathogenic organisms encounter metal stresses in the host environment. ► Pathogens alter their physiology to accommodate iron restriction within the host. ► Copper excess within the host induces multiple forms of toxicity in bacteria.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in microbiology 2012-04, Vol.15 (2), p.169-174
Hauptverfasser:	Wakeman, Catherine A, Skaar, Eric P
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Copper - metabolism Copper - pharmacology enzymes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - genetics Gram-Positive Bacteria - metabolism Gram-Positive Bacteria - pathogenicity Humans ions Iron - metabolism Iron - pharmacology Metals - pharmacology Microbiology pathogens Pathology physiology redox potential toxicity transition elements virulence Virulence Factors - genetics Virulence Factors - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► Pathogenic organisms encounter metal stresses in the host environment. ► Pathogens alter their physiology to accommodate iron restriction within the host. ► Copper excess within the host induces multiple forms of toxicity in bacteria.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2011.11.008