Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir

Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity. All patients had lipoatrophy on a tNRTI-containing regimen with HIV RNA

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Bibliographische Detailangaben
Veröffentlicht in:	Antiviral therapy 2012-01, Vol.17 (2), p.347-353
Hauptverfasser:	MCCOMSEY, Grace A, O'RIORDAN, Maryann, CHOI, Julia, LIBUTTI, Daniel, ROWE, David, STORER, Norma, HARRILL, Danielle, GERSCHENSON, Mariana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Adipocytes - pathology Adipose Tissue - drug effects Adipose Tissue - pathology Adult Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Apoptosis - drug effects Biological and medical sciences Bone Density Dermatology DNA, Mitochondrial - analysis DNA, Mitochondrial - genetics Female HIV Infections - drug therapy HIV Infections - virology HIV-Associated Lipodystrophy Syndrome - drug therapy HIV-Associated Lipodystrophy Syndrome - virology Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Inflammation - pathology Male Medical sciences Middle Aged Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Organophosphonates - pharmacology Organophosphonates - therapeutic use Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - adverse effects RNA - analysis RNA - genetics Skin involvement in other diseases. Miscellaneous. General aspects Tenofovir Uridine - pharmacology Uridine - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Beschreibung
Zusammenfassung:	Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity. All patients had lipoatrophy on a tNRTI-containing regimen with HIV RNA
ISSN:	1359-6535 2040-2058
DOI:	10.3851/IMP1928