Local pulmonary administration of factor VIIa (rFVIIa) in diffuse alveolar hemorrhage (DAH) - a review of a new treatment paradigm

Elucidates the clinical aspects of alveolar haemorrhage. Develops a simple diagnostic algorithm in order to separate diffuse alveolar haemorrhage (DAH) from other important pulmonary diseases with similar clinical picture and comparably high mortality, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and bronchiolitis obliterans organising pneumonia (BOOP), which have different therapies. Evaluates and discusses whether local pulmonary administration may improve outcome and reduce mortality in DAH. Suggests a treatment schedule. Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.