S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells

AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）. METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 28; non-metastasis, n = 20） by reverse transcrip- tion-polymerase chain reaction, quanti...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2012-03, Vol.18 (9), p.915-922
Hauptverfasser:	Chen, Dong, Zheng, Xue-Feng, Yang, Ze-You, Liu, Dong-Xiao, Zhang, Guo-You, Jiao, Xue-Long, Zhao, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadherins - genetics Cadherins - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - physiopathology Esophageal Neoplasms - pathology Esophageal Neoplasms - physiopathology Gene Expression Regulation, Neoplastic Gene Silencing Humans Lymphatic Metastasis - pathology Lymphatic Metastasis - physiopathology Mice Mice, Nude Neoplasm Invasiveness - pathology Neoplasm Invasiveness - physiopathology Original S100 Calcium-Binding Protein A4 S100 Proteins - genetics S100 Proteins - metabolism 侵袭免疫组化方法基因沉默癌细胞能力荧光定量聚合酶链反应食管癌鳞状细胞癌
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Zusammenfassung:	AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）. METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 28; non-metastasis, n = 20） by reverse transcrip- tion-polymerase chain reaction, quantitative polymerase chain reaction and immunohistochemistry. To explore the influence of $100A4 on esophageal cancer invasion and metastasis, $100A4 was overexpressed or silenced by $100A4 siRNA in TE-13 or Eca-109 cells/n vitro and /n vivo.
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v18.i9.915