Association between gastric cancer and - 1993 polymorphism of TBX21 gene

AIM： To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population. METHODS： The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reactionrestriction fragment length polymorphism （PCR-RFLP） method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity. RESULTS： Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio （OR） = 3.42, 95% confidence interval （CI）： 1.41-8.31]. The relation-ship between the -1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients （OR = 4.02, 95% CI： 1.87-8.66; OR = 7.02, 95% CI： 3.44-14.34, respectively）. CONCLUSION： TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.