Pro- and anti-fibrotic effects of TGF-β in scleroderma

Pro- and anti-fibrotic effects of TGF-β in scleroderma

The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-β1) and anti-fibrotic (TGF-β2 and -β3) TGF-β isoforms as a possible cause for fib...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Rheumatology (Oxford, England) England), 2008-10, Vol.47 (suppl-5), p.v5-v7
Hauptverfasser: Sgonc, R., Wick, G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chickens
Fibrosis
Models, Animal
Scleroderma, Systemic - metabolism
Scleroderma, Systemic - pathology
Skin - metabolism
Skin - pathology
Systemic sclerosis
The University of California at Davis 200 chicken
Transforming Growth Factor beta - physiology
Transforming growth factor-β1
Transforming growth factor-β2
Transforming growth factor-β3
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-β1) and anti-fibrotic (TGF-β2 and -β3) TGF-β isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/ken275