Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits

Highlights ► Controlling electrical activity of neurons reveals how they function within circuits. ► Neurons must bear a molecule which converts delivered energy to a voltage change. ► Optogenetic molecular tools sensitize neurons to being controlled with light. ► Thermogenetic molecular tools sensi...

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Veröffentlicht in:	Current opinion in neurobiology 2012-02, Vol.22 (1), p.61-71
Hauptverfasser:	Bernstein, Jacob G, Garrity, Paul A, Boyden, Edward S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - physiology Genetic Techniques - instrumentation Humans Light Neurology Neurons - physiology Neurosciences - instrumentation Neurosciences - methods Optics and Photonics - instrumentation Optics and Photonics - methods Psychiatry Temperature
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights ► Controlling electrical activity of neurons reveals how they function within circuits. ► Neurons must bear a molecule which converts delivered energy to a voltage change. ► Optogenetic molecular tools sensitize neurons to being controlled with light. ► Thermogenetic molecular tools sensitize neurons to being controlled with temperature. ► These tools are in wide experimental use, and may someday be used clinically.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2011.10.023