The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation
Dear Editor, Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 10...
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| Veröffentlicht in: | Cell research 2012-03, Vol.22 (3), p.603-606 |
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| creator | Liu, Li-Juan Liu, Tian-Tian Ran, Yong Li, Ying Zhang, Xiao-Dong Shu, Hong-Bing Wang, Yan-Yi |
| description | Dear Editor,
Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 100 （the precursor of p52） and p 105 （the precursor of p50）. The combinations between them produce a series ofhomodimers and heterodimers, such as p65：p50, c-Rel：p50, p50：p50, and so on, which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells [ 1, 2]. |
| doi_str_mv | 10.1038/cr.2011.199 |
| format | Article |
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Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 100 （the precursor of p52） and p 105 （the precursor of p50）. The combinations between them produce a series ofhomodimers and heterodimers, such as p65：p50, c-Rel：p50, p50：p50, and so on, which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells [ 1, 2].</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2011.199</identifier><identifier>PMID: 22184009</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedical and Life Sciences ; Cell Biology ; HCT116 Cells ; HEK293 Cells ; Humans ; Letter to the Editor ; Life Sciences ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Ubiquitin-Protein Ligases - deficiency ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism ; 免疫反应 ; 基因转录调控 ; 基础 ; 泛素连接酶 ; 激活 ; 调制 ; 负调控 ; 转录因子</subject><ispartof>Cell research, 2012-03, Vol.22 (3), p.603-606</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012</rights><rights>Copyright © 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-6d882e694ee187cb3dd893c0cc3bc960d30abc5ea27c76ac8546a0aae01b0cf33</citedby><cites>FETCH-LOGICAL-c443t-6d882e694ee187cb3dd893c0cc3bc960d30abc5ea27c76ac8546a0aae01b0cf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292294/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292294/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22184009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Li-Juan</creatorcontrib><creatorcontrib>Liu, Tian-Tian</creatorcontrib><creatorcontrib>Ran, Yong</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Zhang, Xiao-Dong</creatorcontrib><creatorcontrib>Shu, Hong-Bing</creatorcontrib><creatorcontrib>Wang, Yan-Yi</creatorcontrib><title>The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Research</addtitle><description>Dear Editor,
Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 100 （the precursor of p52） and p 105 （the precursor of p50）. The combinations between them produce a series ofhomodimers and heterodimers, such as p65：p50, c-Rel：p50, p50：p50, and so on, which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells [ 1, 2].</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>HCT116 Cells</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Letter to the Editor</subject><subject>Life Sciences</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>Ubiquitin-Protein Ligases - deficiency</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><subject>免疫反应</subject><subject>基因转录调控</subject><subject>基础</subject><subject>泛素连接酶</subject><subject>激活</subject><subject>调制</subject><subject>负调控</subject><subject>转录因子</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EoqWwYo_MigVkuP5J4mwq0aqFkQpsytpynDsZVx67YyeV-lhseYg-E65mGMGC1b3S-c65lg8hrxksGAj10aYFB8YWrOuekGPWSlW1SqinZQdgFTTAj8iLnG8AeC1r9pwccc6UBOiOyXC9Rnoh6Ny77ewmF6h3o8lIvy7PGA04msndob-nCcfZmwkz7U02ni4ffp09_KQei0pNGOgmDnvg22VVRGpssRZ7DC_Js5XxGV_t5wn5cXlxff6luvr-eXn-6aqyUoqpagalODadRGSqtb0YBtUJC9aK3nYNDAJMb2s0vLVtY6yqZWPAGATWg10JcUJOd7m3c7_BwWKYkvH6NrmNSfc6Gqf_VYJb6zHeacE7zjtZAt7tA1LczpgnvXHZovcmYJyz7njDalFDXcj3O9KmmHPC1eEKA_1Yi7ZJP9aiSy2FfvP3ww7snx4K8GEH5CKFEZO-iXMK5bP-k_d2f30dw7gtjkOkZLzlbQviN6J3pYc</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Liu, Li-Juan</creator><creator>Liu, Tian-Tian</creator><creator>Ran, Yong</creator><creator>Li, Ying</creator><creator>Zhang, Xiao-Dong</creator><creator>Shu, Hong-Bing</creator><creator>Wang, Yan-Yi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation</title><author>Liu, Li-Juan ; Liu, Tian-Tian ; Ran, Yong ; Li, Ying ; Zhang, Xiao-Dong ; Shu, Hong-Bing ; Wang, Yan-Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-6d882e694ee187cb3dd893c0cc3bc960d30abc5ea27c76ac8546a0aae01b0cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>HCT116 Cells</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>Letter to the Editor</topic><topic>Life Sciences</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - metabolism</topic><topic>Ubiquitin-Protein Ligases - deficiency</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><topic>免疫反应</topic><topic>基因转录调控</topic><topic>基础</topic><topic>泛素连接酶</topic><topic>激活</topic><topic>调制</topic><topic>负调控</topic><topic>转录因子</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Li-Juan</creatorcontrib><creatorcontrib>Liu, Tian-Tian</creatorcontrib><creatorcontrib>Ran, Yong</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Zhang, Xiao-Dong</creatorcontrib><creatorcontrib>Shu, Hong-Bing</creatorcontrib><creatorcontrib>Wang, Yan-Yi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li-Juan</au><au>Liu, Tian-Tian</au><au>Ran, Yong</au><au>Li, Ying</au><au>Zhang, Xiao-Dong</au><au>Shu, Hong-Bing</au><au>Wang, Yan-Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation</atitle><jtitle>Cell research</jtitle><stitle>Cell Res</stitle><addtitle>Cell Research</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>22</volume><issue>3</issue><spage>603</spage><epage>606</epage><pages>603-606</pages><issn>1001-0602</issn><eissn>1748-7838</eissn><abstract>Dear Editor,
Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 100 （the precursor of p52） and p 105 （the precursor of p50）. The combinations between them produce a series ofhomodimers and heterodimers, such as p65：p50, c-Rel：p50, p50：p50, and so on, which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells [ 1, 2].</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22184009</pmid><doi>10.1038/cr.2011.199</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PMC (PubMed Central); EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Cell Biology HCT116 Cells HEK293 Cells Humans Letter to the Editor Life Sciences NF-kappa B - genetics NF-kappa B - metabolism Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism 免疫反应 基因转录调控 基础 泛素连接酶 激活 调制 负调控 转录因子 |
| title | The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation |
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