The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation

Dear Editor, Nuclear factor （NF）-nB is a family of transcription factors, which are critically involved in regulation of divergent physiological and pathological processes, such as apoptosis, tumorigenesis and immune response. The NF- nB family consists of five members, p65 （RelA）, RelB, c-Rel, p 100 （the precursor of p52） and p 105 （the precursor of p50）. The combinations between them produce a series ofhomodimers and heterodimers, such as p65：p50, c-Rel：p50, p50：p50, and so on, which play central roles in transcriptional regulation of genes involved in a wide range of functions from adaptive and innate immune responses to development of immune cells [ 1, 2].