Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction
Patients with CAD and LV dysfunction were assigned to receive either medical therapy alone or medical therapy plus CABG. There was no evidence of significant interaction between myocardial viability and treatment assignment. Coronary artery disease is an important contributor to the rise in the prev...
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| Veröffentlicht in: | The New England journal of medicine 2011-04, Vol.364 (17), p.1617-1625 |
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| creator | Bonow, Robert O Maurer, Gerald Lee, Kerry L Holly, Thomas A Binkley, Philip F Desvigne-Nickens, Patrice Drozdz, Jaroslaw Farsky, Pedro S Feldman, Arthur M Doenst, Torsten Michler, Robert E Berman, Daniel S Nicolau, Jose C Pellikka, Patricia A Wrobel, Krzysztof Alotti, Nasri Asch, Federico M Favaloro, Liliana E She, Lilin Velazquez, Eric J Jones, Robert H Panza, Julio A |
| description | Patients with CAD and LV dysfunction were assigned to receive either medical therapy alone or medical therapy plus CABG. There was no evidence of significant interaction between myocardial viability and treatment assignment.
Coronary artery disease is an important contributor to the rise in the prevalence of heart failure and in associated mortality and morbidity.
1
–
4
It has not been clearly established whether coronary-artery bypass grafting (CABG) has a role in improving the symptoms and the rate of survival of patients with coronary artery disease and heart failure. We conducted the multicenter Surgical Treatment for Ischemic Heart Failure (STICH) trial
5
,
6
to examine two hypotheses, one of which (hypothesis 1) compared the efficacy of medical therapy alone with that of medical therapy plus CABG in patients with coronary artery disease and left ventricular . . . |
| doi_str_mv | 10.1056/NEJMoa1100358 |
| format | Article |
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Coronary artery disease is an important contributor to the rise in the prevalence of heart failure and in associated mortality and morbidity.
1
–
4
It has not been clearly established whether coronary-artery bypass grafting (CABG) has a role in improving the symptoms and the rate of survival of patients with coronary artery disease and heart failure. We conducted the multicenter Surgical Treatment for Ischemic Heart Failure (STICH) trial
5
,
6
to examine two hypotheses, one of which (hypothesis 1) compared the efficacy of medical therapy alone with that of medical therapy plus CABG in patients with coronary artery disease and left ventricular . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1100358</identifier><identifier>PMID: 21463153</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Cardiovascular disease ; Cardiovascular Diseases - mortality ; Combined Modality Therapy ; Coronary Artery Bypass ; Coronary Artery Disease - complications ; Coronary Artery Disease - drug therapy ; Coronary Artery Disease - surgery ; Coronary vessels ; Echocardiography, Stress ; Female ; Follow-Up Studies ; Heart attacks ; Heart Failure - drug therapy ; Heart Failure - etiology ; Heart Failure - surgery ; Humans ; Hypotheses ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Myocardial Ischemia ; Myocardium - pathology ; Patients ; Proportional Hazards Models ; Statistics, Nonparametric ; Studies ; Tomography, Emission-Computed, Single-Photon ; Ventricular Dysfunction, Left - drug therapy ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - surgery</subject><ispartof>The New England journal of medicine, 2011-04, Vol.364 (17), p.1617-1625</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2011 Massachusetts Medical Society. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-a5d4359321993282c8f6ee14cd826b92a69f93fbb6c05a47d327c9bb871e81d3</citedby><cites>FETCH-LOGICAL-c509t-a5d4359321993282c8f6ee14cd826b92a69f93fbb6c05a47d327c9bb871e81d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1100358$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/868663422?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21463153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonow, Robert O</creatorcontrib><creatorcontrib>Maurer, Gerald</creatorcontrib><creatorcontrib>Lee, Kerry L</creatorcontrib><creatorcontrib>Holly, Thomas A</creatorcontrib><creatorcontrib>Binkley, Philip F</creatorcontrib><creatorcontrib>Desvigne-Nickens, Patrice</creatorcontrib><creatorcontrib>Drozdz, Jaroslaw</creatorcontrib><creatorcontrib>Farsky, Pedro S</creatorcontrib><creatorcontrib>Feldman, Arthur M</creatorcontrib><creatorcontrib>Doenst, Torsten</creatorcontrib><creatorcontrib>Michler, Robert E</creatorcontrib><creatorcontrib>Berman, Daniel S</creatorcontrib><creatorcontrib>Nicolau, Jose C</creatorcontrib><creatorcontrib>Pellikka, Patricia A</creatorcontrib><creatorcontrib>Wrobel, Krzysztof</creatorcontrib><creatorcontrib>Alotti, Nasri</creatorcontrib><creatorcontrib>Asch, Federico M</creatorcontrib><creatorcontrib>Favaloro, Liliana E</creatorcontrib><creatorcontrib>She, Lilin</creatorcontrib><creatorcontrib>Velazquez, Eric J</creatorcontrib><creatorcontrib>Jones, Robert H</creatorcontrib><creatorcontrib>Panza, Julio A</creatorcontrib><creatorcontrib>STICH Trial Investigators</creatorcontrib><title>Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Patients with CAD and LV dysfunction were assigned to receive either medical therapy alone or medical therapy plus CABG. There was no evidence of significant interaction between myocardial viability and treatment assignment.
Coronary artery disease is an important contributor to the rise in the prevalence of heart failure and in associated mortality and morbidity.
1
–
4
It has not been clearly established whether coronary-artery bypass grafting (CABG) has a role in improving the symptoms and the rate of survival of patients with coronary artery disease and heart failure. We conducted the multicenter Surgical Treatment for Ischemic Heart Failure (STICH) trial
5
,
6
to examine two hypotheses, one of which (hypothesis 1) compared the efficacy of medical therapy alone with that of medical therapy plus CABG in patients with coronary artery disease and left ventricular . . .</description><subject>Aged</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Combined Modality Therapy</subject><subject>Coronary Artery Bypass</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary vessels</subject><subject>Echocardiography, Stress</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - surgery</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia</subject><subject>Myocardium - pathology</subject><subject>Patients</subject><subject>Proportional Hazards Models</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Ventricular Dysfunction, Left - drug therapy</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - surgery</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10c1LwzAYBvAgipsfR69SBPFUzVez5CLInF9MPSheQ5qmmtEmmrSD_fdGNocK5pBA8uPhCS8ABwieIliws4fJ3b1XCEFICr4BhqggJKcUsk0whBDznI4EGYCdGGcwLUTFNhhgRBlJcgju7hdeq1BZ1WQvVpW2sd0iU67Knvowt_N0bV12G_Wbaa3OpqbushfjumB136iQXS5i3TvdWe_2wFatmmj2V-cueL6aPI9v8unj9e34YprrAoouV0VFSSEIRiJtHGteM2MQ1RXHrBRYMVELUpcl07BQdFQRPNKiLPkIGY4qsgvOl7HvfdmaSn-VUY18D7ZVYSG9svL3i7Nv8tXPJcECCohSwMkqIPiP3sROtjZq0zTKGd9HyRlFAgkMkzz6I2e-Dy59LiHOGKEYJ5QvkQ4-xmDqdRUE5deI5K8RJX_4s_9af88kgeMlaNsonZm1_wR9An3NmA0</recordid><startdate>20110428</startdate><enddate>20110428</enddate><creator>Bonow, Robert O</creator><creator>Maurer, Gerald</creator><creator>Lee, Kerry L</creator><creator>Holly, Thomas A</creator><creator>Binkley, Philip F</creator><creator>Desvigne-Nickens, Patrice</creator><creator>Drozdz, Jaroslaw</creator><creator>Farsky, Pedro S</creator><creator>Feldman, Arthur M</creator><creator>Doenst, Torsten</creator><creator>Michler, Robert E</creator><creator>Berman, Daniel S</creator><creator>Nicolau, Jose C</creator><creator>Pellikka, Patricia A</creator><creator>Wrobel, Krzysztof</creator><creator>Alotti, Nasri</creator><creator>Asch, Federico M</creator><creator>Favaloro, Liliana E</creator><creator>She, Lilin</creator><creator>Velazquez, Eric J</creator><creator>Jones, Robert H</creator><creator>Panza, Julio A</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110428</creationdate><title>Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction</title><author>Bonow, Robert O ; Maurer, Gerald ; Lee, Kerry L ; Holly, Thomas A ; Binkley, Philip F ; Desvigne-Nickens, Patrice ; Drozdz, Jaroslaw ; Farsky, Pedro S ; Feldman, Arthur M ; Doenst, Torsten ; Michler, Robert E ; Berman, Daniel S ; Nicolau, Jose C ; Pellikka, Patricia A ; Wrobel, Krzysztof ; Alotti, Nasri ; Asch, Federico M ; Favaloro, Liliana E ; She, Lilin ; Velazquez, Eric J ; Jones, Robert H ; Panza, Julio A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-a5d4359321993282c8f6ee14cd826b92a69f93fbb6c05a47d327c9bb871e81d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - 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There was no evidence of significant interaction between myocardial viability and treatment assignment.
Coronary artery disease is an important contributor to the rise in the prevalence of heart failure and in associated mortality and morbidity.
1
–
4
It has not been clearly established whether coronary-artery bypass grafting (CABG) has a role in improving the symptoms and the rate of survival of patients with coronary artery disease and heart failure. We conducted the multicenter Surgical Treatment for Ischemic Heart Failure (STICH) trial
5
,
6
to examine two hypotheses, one of which (hypothesis 1) compared the efficacy of medical therapy alone with that of medical therapy plus CABG in patients with coronary artery disease and left ventricular . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>21463153</pmid><doi>10.1056/NEJMoa1100358</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2011-04, Vol.364 (17), p.1617-1625 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged Cardiovascular disease Cardiovascular Diseases - mortality Combined Modality Therapy Coronary Artery Bypass Coronary Artery Disease - complications Coronary Artery Disease - drug therapy Coronary Artery Disease - surgery Coronary vessels Echocardiography, Stress Female Follow-Up Studies Heart attacks Heart Failure - drug therapy Heart Failure - etiology Heart Failure - surgery Humans Hypotheses Kaplan-Meier Estimate Male Middle Aged Myocardial Ischemia Myocardium - pathology Patients Proportional Hazards Models Statistics, Nonparametric Studies Tomography, Emission-Computed, Single-Photon Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - surgery |
| title | Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction |
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