Phenotypic analysis of pneumococcal polysaccharide-specific B cells

The phenotype of B cells responsible for the production of anti-pneumococcal polysaccharide Ab has been unclear. Although individuals that respond poorly to the 23-valent pneumococcal polysaccharide (PPS) vaccine, Pneumovax, such as children

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-03, Vol.188 (5), p.2455-2463
Hauptverfasser:	Khaskhely, Noor, Mosakowski, Jason, Thompson, Rebecca S, Khuder, Sadik, Smithson, S Louise, Westerink, M A Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Bacterial Capsules - immunology Bacterial Capsules - metabolism Binding Sites, Antibody Binding, Competitive - immunology Epitopes, B-Lymphocyte - immunology Epitopes, B-Lymphocyte - metabolism Humans Hybridomas Immunoglobulin A - biosynthesis Immunoglobulin A - metabolism Immunoglobulin G - biosynthesis Immunoglobulin G - metabolism Immunoglobulin M - biosynthesis Immunoglobulin M - metabolism Immunologic Memory Immunophenotyping - methods Mice Pneumococcal Vaccines - immunology Pneumococcal Vaccines - metabolism Streptococcus pneumoniae Young Adult
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Beschreibung
Zusammenfassung:	The phenotype of B cells responsible for the production of anti-pneumococcal polysaccharide Ab has been unclear. Although individuals that respond poorly to the 23-valent pneumococcal polysaccharide (PPS) vaccine, Pneumovax, such as children
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.1102809