Two sequence-tagged sites defining the ends of a 380 kb YAC clone from 19q13

The genetic markers D19S51 and ERCC-1 flank the myotonic dystrophy locus on chromosome 19q13 and define a region of approximately 1 Mb in the human genome within which the gene responsible for this autosomal dominant disease resides. Partial sequencing of the D19S51 locus has allowed screening of a...

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Veröffentlicht in:	Nucleic acids research 1991-09, Vol.19 (17), p.4787-4787
Hauptverfasser:	BUTLER, R, RILEY, J. H, OGILVIE, D. J, ANAND, R, BUXTON, J, DAVIES, J, JOHNSON, K, MARKHAM, A. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences chromosome 19 Chromosomes, Fungal Chromosomes, Human, Pair 19 Classical genetics, quantitative genetics, hybrids DNA, Single-Stranded - genetics Fundamental and applied biological sciences. Psychology Genetic Markers - genetics Genetics of eukaryotes. Biological and molecular evolution genomes Human Humans Molecular Sequence Data Myotonic Dystrophy - genetics Polymerase Chain Reaction Sequence Tagged Sites
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Zusammenfassung:	The genetic markers D19S51 and ERCC-1 flank the myotonic dystrophy locus on chromosome 19q13 and define a region of approximately 1 Mb in the human genome within which the gene responsible for this autosomal dominant disease resides. Partial sequencing of the D19S51 locus has allowed screening of a gridded yeast artificial chromosome (YAC) library with a view to assembling a YAC contig for this region. Sequencing of both ends of the insert in a YAC (8IC8) identified in this manner has generated two sequence-tagged sites for D19S51 separated by 380 Kb in the human genome.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/19.17.4787