Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality

Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality

Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment m...

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Veröffentlicht in:Clinical infectious diseases 2012-03, Vol.54 (5), p.701-705
Hauptverfasser: Wall, Emma C., Gordon, Stephen B., Hussain, Samia, Goonetilleke, Upali R. S., Gritzfeld, Jenna, Scarborough, Matthew, Kadioglu, Aras
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Animal models
Antibiotics
Bacterial diseases
Bacterial Load
Bacterial meningitis
Bacterial Proteins - cerebrospinal fluid
Biological and medical sciences
BRIEF REPORTS
Cerebrospinal fluid
Cerebrospinal Fluid - microbiology
DNA
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Medical treatment
Meningitis
Meningitis, Pneumococcal - cerebrospinal fluid
Meningitis, Pneumococcal - mortality
Mortality
Neuraminidase - cerebrospinal fluid
Pneumococcal meningitis
Spinal cord
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus pneumoniae
Streptolysins - cerebrospinal fluid
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Zusammenfassung:Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cir926